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Abstract #2920

Multi-site/Multi-vendor reproducibility of advanced MRS at 3T in a clinical cohort

James M Joers1, Dinesh K Deelchand1, Bin Guo2, Lynn E Eberly2, Young Woo Park1, Adam Berrington3, Michal Povazan4, Andre van der Kouwe5, Khalaf Bushara6, Chiadi U Onyike7, Jeremy Schmahmann8, Peter B Barker4,9, Eva Ratai5, and Gülin Öz1
1CMRR/Radiology, University of Minnesota, Minneapolis, MN, United States, 2Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, 3Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom, 4Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 5A.A. Martinos Center for Biomedical Imaging / Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States, 6Neurology, University of Minnesota Medical School, Minneapolis, MN, United States, 7Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, United States, 8Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States, 9Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States

The reproducibility of an advanced single voxel MRS protocol was tested in a clinical cohort and control subjects at 3T in a multi-site setting. A standardized MRS protocol was implemented on two MR system vendors (Siemens, Philips) over three sites. This protocol utilized automated voxel placement and an sLASER pulse sequence with identical radiofrequency waveforms, pulse durations, interpulse delays and gradient spoilers. Spectral quality, metabolite concentrations and test-retest reproducibility results from three voxels are reported from both the healthy control group and subjects with genetically-confirmed spinocerebellar ataxia type 3 (SCA3), a hereditary movement disorder.

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