Lactate is an important marker of tumor metabolism. We have previously reported the Hadamard slice selected, selective multiple quantum coherence chemical shift imaging sequence for a 3T clinical scanner to image lactate in the human body. Here we report modification and optimization of the sequence for reducing motion effect and increasing lipid suppression while retaining lactate. A coherence selection gradient ratio of a:-1:2 with nonzero a provided improved suppression of lipid resonances at 1.3 ppm and 0.9 ppm compared to the previous 0:-1:2 ratio. Optimization of RF pulses blocked occurrence of MQC between lipid 2.0 ppm and 5.3 ppm resonances.
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