Abstract #2897

MODIFIED HERCULES MULTI-METABOLITE EDITING with SEMI-LASER LOCALIZATION at 3T

Steve CN Hui^1,2, Muhammad G Saleh^1,2, Georg Oeltzschner^1,2, Mark Mikkelsen^1,2, Sofie Tapper^1,2, and Richard AE Edden^1,2

¹Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

An improved editing scheme was proposed for the Hadamard Editing Resolves Chemicals Using Linear-combination Estimation of Spectra (HERCULES). The original editing pulse at 4.18 ppm was replaced by a new wider-band pulse at 4.04 ppm to facilitate signal acquisition for aspartate, ascorbate and lactate. Furthermore, the new scheme (HERCULES-2) was implemented within the semi-LASER and PRESS sequences. HERCULES-2 with semi-LASER yielded increases in overall signal intensities in most targeted metabolites, robust to B₁ inhomogeneity, facilitating the precise quantification of edited spectra.

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