Signal combination algorithms, designed for 1D MRS, were adapted for lipid composition spectra acquired using 2D MRS of double quantum filtered correlation spectroscopy (DQF-COSY). The algorithms of adaptively optimised combination (AOC), noise decorrelated combination (nd-comb), and whitened singular value decomposition (WSVD) were evaluated on lipid composition spectra from healthy volunteers and patients with breast cancer (tumour and peritumoural adipose tissue). WSVD provided maximal SNR uniformly across all spectral peaks. WSVD, through the elimination of additional acquired reference spectrum, shortens acquisition in patients to less than 11 min instead of 17 min while maintaining sensitivity.
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