Abstract #2839

23Na MRI of human intervertebral cervical discs in Mucopolysaccharidosis type II

Lenka Minarikova¹, Alena Svatkova², Wolfgang Bogner¹, Siegfried Trattnig^1,3, Thomas Stulnig², and Stephan Gruber¹

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Clinical Division for Endocrinology and Metabolism, Department of Medicine III, Medical University of Vienna, Vienna, Austria, ³CD Laboratory for Clinical Molecular MR Imaging, Vienna, Austria

Spinal skeletal disease is one of least therapy responding symptoms in MPS patients. Cervical spine of three MPS II patients and three matched controls was measured using ²³Na MRI at 7T. There was a significant difference in intervertebral discs of MPS II patient compared to controls. ²³Na MRI represents a potential quantitative method for assessment of cervical disc degeneration in MPS II patients and could serve as a potential marker used in monitoring of emerging therapies.

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