Abstract #2837

Assessment of skeletal muscle pathology in Dystrophin-deficient mice using structural and functional Diffusion MRI

Rina Ito^1,2, Junichi Hata^3,4, Mayu Iida^1,2, Fumiko Seki², Mitsuki Rikitake^1,2, Yuji Komaki², Chihoko Yamada², Daisuke Nakashima⁴, Hirotaka James Okano^3,4, and Takako Shirakawa¹

¹Department of Radiology, Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ²Live Imaging Center, Central Institute for Experimental Animals, Kanagawa, Japan, ³Jikei University School of Medicine, Tokyo, Japan, ⁴Keio University School of Medicine, Tokyo, Japan

To analyze the disease of muscular dystrophy noninvasively, we assessed the degeneration of skeletal muscle and the distinction depending on types of muscle fibers, with changing parameters based on the sequence of diffusion weighted imaging. The mdx mice were used for longitudinal evaluation at the age from 5 to 10 weeks. We confirmed conventional diffusion tensor imaging could evaluate the pathological structure. Moreover, by applying the advanced imaging such as time-dependent diffusion MRI, we could demonstrate the functional characteristics of skeletal muscle cell and to detect micro-level condition of degeneration in mdx-mice.

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