Abstract #2679

Differentiating ALTs/DDLs from benign lipomas using high-resolution 1H MR Spectroscopy

Santosh K Bharti¹, Brett A. Shannon², Raj Kumar Sharma¹, Adam Levin², Carol Morris², Laura Fayad^2,3, and Zaver M. Bhujwalla^1,4,5

¹Div. of Cancer Imaging Research, The Russell H. Morgan Dept of Radiology and Radiological Science, The Johns Hopkins University School of Medicine,, Baltimore, MD, United States, ²Department of Orthopaedic Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Musculoskeletal Radiology, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵3Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Adipocytic tumors present a spectrum of neoplastic disease including benign lipomas, atypical lipomatous tumors (ALTs), and malignant liposarcomas DDLs. Distinguishing high-grade liposarcomas (DDLs-dedifferentiated liposarcomas) and premalignant ALTs from benign lipomas can be a diagnostic challenge with implications for surgical and clinical management. Our study demonstrate that high-resolution 1H magnetic resonance spectroscopy (MRS) may be used as an additional method for classification and differential diagnosis of ALTs from benign lipomas. Metabolic analysis clearly reflects the metabolic changes associated with malignant progression.

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