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Abstract #2621

Flow quantification with navigator-gated 4D flow MRI in portal hypertension 

Octavia Bane1,2, Daniel Stocker1,2, Paul Kennedy1,2, Stefanie Hectors1,2,3, Susanne Schnell4, Scott Friedman5, Thomas Schiano5, Isabel M Fiel6, Swan Thung6, Aaron Fischman2, Michael Markl4,7, and Bachir Taouli1,2
1BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Radiology, Weill Cornell Medicine, New York, NY, United States, 4Department of Radiology, Northwestern University, Chicago, IL, United States, 5Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 6Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 7Biomedical Engineering, Northwestern University McCormick School of Engineering, Evanston, IL, United States

The purpose of our prospective study was to correlate the hepatic vasculature hemodynamic parameters measured with navigator-gated 4D flow MRI with the hepatic venous pressure gradient (HVPG) in patients with chronic liver disease and suspicion of portal hypertension (PH). Peak velocity in the celiac trunk (CT) was moderately correlated with HVPG, and was significantly elevated in patients with PH. CT flow was significantly elevated in patients with clinically significant PH (CSPH), while portal vein peak velocity was significantly reduced in patients with cirrhosis. Our results suggest that 4D flow MRI may be sensitive to hemodynamic changes in patients with PH.

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