Conventional liver diffusion MRI acquisitions suffer from several challenges including low spatial resolution, B0-induced distortions, and elastic motion-induced signal voids. In this work, motion-robust and distortion-corrected liver diffusion-weighted imaging (DWI) was enabled by combining optimized motion compensated diffusion waveforms with multi-shot EPI acquisitions. Quantitative validation of distortions and ADC measurements was performed in healthy volunteer to assess the robustness and reproducibility of the combined techniques, as well as the synergistic effect of motion-robust gradient waveform and multi-shot EPI acquisitions. Preliminary patient example demonstrated the feasibility in patients with metastatic liver lesions.
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