Cold exposure is the commonly used method in evaluating the brown adipose tissue (BAT) activation. In this study, the heat production capacity of BAT in rats housed at different ambient temperatures were evaluated using magnetic resonance thermometry after injecting norepinephrine (NE). The results show that the rats housed at lower ambient temperature (15°C) for 2 weeks have surprisingly lower temperature rise after NE injection, implying that long-term cold exposed rats have lower heat production capacity after drug activation.
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