Abstract #2553

Using 1H MRS to Investigate Hepatic Fat Fractions and Lipid Composition in NAFLD Patients with Type 2 Diabetes

Stephen Bawden^1,2, Scott Willis³, Aron Sherry³, Penny Gowland², James King³, and Guruprasad P Aithal¹

¹NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, United Kingdom, ²Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ³School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom

1H MRS offers unique insights into hepatic lipid composition. In this study, NAFLD patients with and without Type 2 Diabetes were scanned and hepatic lipid composition indices measured. Diabetic patients then underwent a randomized controlled trial to investigate the effectiveness of 6 weeks moderate exercise vs control. Lipid composition indices were similar to previous studies in obesity, and show no differences in diabetic v non-diabetic groups. The intervention also shows no change in hepatic fat fraction or lipid composition.

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