Abstract #2440

IVIM-DKI analysis using Hybrid model with parameter reconstruction method in prostate cancer at 1.5T vs 3T MRI

Archana Vadiraj Malagi¹, Arjun Lokesh², Esha Baidya Kayal¹, Kedar Khare³, Virendra Kumar⁴, Chandan J. Das², and Amit Mehndiratta^1,5

¹Centre for Biomedical Engineering, Indian Institute of Technology Delhi, New Delhi, India, ²Department of Radiodiagnosis, All India Institute of Medical Sciences Delhi, New Delhi, India, ³Department of Physics, Indian Institute of Technology Delhi, New Delhi, India, ⁴Department of Nuclear Magnetic Resonance (NMR), All India Institute of Medical Sciences Delhi, New Delhi, India, ⁵Department of Biomedical Engineering, All India Institute of Medical Sciences Delhi, New Delhi, India

Currently in countries with poor resources availability of higher magnetic strength 3T MRI is low. Objective is to analyze whether with lower magnetic strength 1.5T MRI with advanced parameter reconstruction method can perform better or equivalent to 3T MRI. IVIM-DKI signal was modelled using hybrid (HY) model which produces non-physiological inhomogeneity in parameter map. This inhomogeneity can be corrected by using total variation penalty function (TV) with HY model. IVIM-DKI maps obtained from HY with TV produced more clinically reliable than HY model. Even with low magnetic strength i.e. 1.5T, overall HY+TV model outperformed qualitatively & quantitatively against 3T MRI results.

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