Abstract #2417

Differentiation of Prostate Cancer from Benign Prostatic Hyperplasia using Whole-lesion Histogram Analysis on Diffusion-weighted Imaging

Luguang Chen¹, Pengyi Xin¹, Qingsong Yang¹, Tao Song¹, Chao Ma¹, Robert Grimm², Caixia Fu³, and Jianping Lu¹

¹Radiology, Changhai Hospital of Shanghai, Shanghai, China, ²Application Predevelopment, Siemens Healthcare, Erlangen, Germany, ³Application Development, Siemens Shenzhen Magnetic Resonace Ltd, Shenzhen, China

Histogram and texture analysis have the potential in evaluating the heterogeneous features of tumors. This study aimed to assess the usefulness of histogram and texture analysis of ADC maps for differentiating PCa from BPH with pathology as the reference. 90 PCa and 112 BPH patients were enrolled and analyzed using histogram and texture analyses. Significant differences were observed in age, PSA, lesion volume and histogram parameters (except kurtosis) of ADC map between the PCa and BPH patients. The whole-lesion histogram and texture analysis-based parameters from the quantitative ADC map may serve as a useful biological characterization of prostate cancer.

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