The fleeting nature of hyperpolarized xenon-129 magnetization necessitates a separate flip angle calibration procedure based on the decay of the gas-phase signal. This calibration is subsequently assumed to be valid for imaging of the xenon dissolved in the lung tissue despite the rapid exchange between the parenchyma and the alveolar gas volume and despite that the T2* is much shorter in the former than in the latter. In this work we implemented a 1-dimensional gas exchange simulation and investigated to what extent the effective flip angle at the dissolved-phase frequencies is affected by exchange and acquisition parameters.
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