Abstract #2367

Phase imaging of hyperpolarized 129Xe gas in a human lung

Gang Zheng¹, Wai Tung Lee^2,3, Xin Tong⁴, Tim D’Adam², Steven Parnell⁵, Michael de Veer¹, Shenpeng Li¹, Hongxin Wang¹, Richard Mcintyre¹, Francis Thien⁶, and Gary Egan¹

¹Monash Biomedical Imaging, Monash University, Clayton, Australia, ²Australian Nuclear Science and Technology Organisation, Lucas Heights, Australia, ³Instrument Technologies Division, European Spallation Source ERIC, Lund, Sweden, ⁴China Spallation Neutron Source, Dongguan, China, ⁵Delft University of Technical, Delft, Netherlands, ⁶Eastern Clinical School, Monash University, Box Hill, Australia

We describe a custom-designed spin-exchange-optical pumping (SEOP) polarizer which can reliably produce hyperpolarized 129-Xe (HP-Xe) gas. Imaging of a HP-Xe phantom showed phase images were less sensitive to depolarization and could provide on/off images of HP-Xe. In a human lung, phase image provided higher imaging contrast in low HP-Xe polarization states.

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