Abstract #2343

Quantify the Influence of Smoking on Pulmonary Structure and Function in Lung Cancer Patients using Hyperpolarized 129Xe MR

Qian Zhou¹, Haidong Li¹, Qiuchen Rao¹, Junshuai Xie¹, Xiuchao Zhao¹, He Deng¹, Lei Shi¹, Xianping Sun¹, Yeqing Han¹, Dongshan Han², Xin Lou², Chaohui Ye¹, and Xin Zhou¹

¹National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Wuhan, China, ²Department of Radiology, Chinese PLA General Hospital, Beijing, P. R. China, Beijing, China

Pulmonary diseases, such as lung cancer, usually result in changes of pulmonary structure and function. To assess these changes, gas exchange across the respiratory membrane and gas diffusion in the alveoli can be quantified using hyperpolarized ¹²⁹Xe MR via CSSR and DWI in lung cancer patients, The significant differences were found in mean exchange time constant(T) and septal wall thickness(d) between smoking and non-smoking lung cancer patients, indicating the impact of smoking. The results manifested that the hyperpolarized ¹²⁹Xe MR is a promising method for optimizing radiation therapy in the future.

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