Abstract #2305

Repeatability and correlation of hyperpolarized xenon-129 and oxygen enhanced MRI parameters in healthy volunteers

Paul J.C. Hughes¹, Marta Tibiletti², Matthew J. Heaton², Ho-Fung Chan¹, Guilhem J. Collier¹, Matthew Austin¹, Laurie J. Smith^1,3, Jim Lithgow¹, Josephine H. Naish^2,4, Jim M. Wild^1,5, and Geoff J.M. Parker^2,6

¹POLARIS, Department of Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom, ²Bioxydyn, Manchester, United Kingdom, ³Sheffield Children's Hospital NHS Foundation Trust, Sheffield, United Kingdom, ⁴Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom, ⁵Insigneo Institute for in silico Medicine, The University of Sheffield, Sheffield, United Kingdom, ⁶Centre for Medical Image Computing, University College London, London, United Kingdom

Hyperpolarised xenon-129 MRI has shown utility in longitudinal assessment of lung structure and function, and has been shown to be a repeatable method. Oxygen enhanced MRI is a cheaper method of imaging different aspects of lung function. This work aimed to assess a single-centre repeatability of multiple metrics from both imaging methods in volunteers, and assess any correlations between xenon-129 and oxygen enhanced metrics of lung function.

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