Abstract #2285

Regional hyperpolarised 129-xenon MR spectroscopy and diffusion-weighted MRI in patients with idiopathic pulmonary fibrosis

James A Eaden^1,2, Ho-Fung Chan¹, Guilhem J Collier¹, Nicholas D Weatherley¹, Jim Lithgow¹, Oliver Rodgers¹, Jody FD Bray¹, Graham Norquay¹, Stephen M Bianchi², and Jim M Wild^1,3

¹POLARIS, MRI unit, Department of Infection Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, ²Academic Directorate of Respiratory Medicine, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, ³Insigneo institute, University of Sheffield, Sheffield, United Kingdom

Preliminary findings are presented from a prospective, longitudinal hyperpolarised ¹²⁹Xe MRI study of idiopathic pulmonary fibrosis patients. To date, 28 patients have undergone baseline ¹²⁹Xe DW-MRI and 10 patients have returned for a six-month scan. 14 patients have undergone baseline dissolved ¹²⁹Xe imaging using IDEAL CSI method. Regional values were produced by separating the lung into three zones. We demonstrate regional differences in ¹²⁹Xe gas transfer and ¹²⁹Xe DW-MRI measurements. Lm_D was found to be more sensitive to longitudinal change than ADC. Over a six-month period, the significant change in mean ¹²⁹Xe Lm_D was observed in the lower zone only.

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