Abstract #2283

Noninvasive Diagnosis of Pulmonary Hypertension with Hyperpolarized 129Xe Magnetic Resonance Imaging and Spectroscopy

Elianna Ada Bier¹, Ziyi Wang¹, Hamid Chalian², Joseph Mammarappallil², John C Nouls², Leith Rankine³, Junlan Lu³, Bastiaan Driehuys², and Sudarshan Rajagopal⁴

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Radiology, Duke University Medical Center, Durham, NC, United States, ³Medical Physics Graduate Program, Duke University, Durham, NC, United States, ⁴Division of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, United States

Using unique signatures in ¹²⁹Xe MR 3D gas exchange imaging and dynamic spectroscopy, we tested an algorithm to detect pulmonary hypertension (PH). The algorithm was developed using a training cohort (n=105) and tested on 25 subjects whose PH status was determined via right heart catheterization. Two expert readers rated scan quality and interpreted each subject’s ¹²⁹Xe MRI/MRS to determine PH status. Using the 16 patients for which readers rated scan diagnostic quality as 4-5/5, the diagnostic accuracy was 0.84 (sensitivity=0.78, specificity=0.93). This model demonstrates the ability to distinguish subjects with pre-capillary PH from those without PH or with post-capillary PH.

This abstract and the presentation materials are available to members only; a login is required.

Join Here