Abstract #2248

Vascular Imaging of the Human Kidney with Positive Contrast via SPION and UTE

Liam Timms¹, Tianyi Zhou¹, Ju Qiao², Vishala Mishra³, Gayatri Veeramani^4,5, Andrew Allegretti⁴, Thomas Benkert⁶, John Kirsch², Ravi Seethamraju⁷, Mukesh Harisinghani³, and Srinivas Sridhar^1,8

¹Physics, Northeastern University, Boston, MA, United States, ²Massachusetts General Hospital, Boston, MA, United States, ³Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁴Nephrology, Massachusetts General Hospital, Boston, MA, United States, ⁵Nephrology, Brigham and Women’s Hospital, Boston, MA, United States, ⁶Siemens Healthcare, Erlangen, Germany, ⁷Siemens Healthcare, Boston, MA, United States, ⁸Theranano LLC, Newton, MA, United States

A contrast-enhanced MRA technique using Ultra-short Time-to-Echo (UTE) pulse sequence with super-paramagnetic iron oxide nanoparticle (SPION) contrast agent is demonstrated for abdominal vascular imaging in human patients. It successfully depicts the kidney anatomy, as well as kidney cysts and kidney vascular structure in excellent clarity and detail. With manual segmentation, total kidney volume, cyst volume and renal artery diameter were estimated. This initial study in humans demonstrated the basic feasibility of abdominal QUTE-CE MRA as an alternative to Gd based CEMRA.

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