Abstract #2243

Using Novel Fat Water Separation Sequence to Quantify Intramyocardial Fat-Fraction

Xin Dong^1,2, Olumide Awelewa ^1,2, Graham Galloway², Viral Chikani³, Rob Robergs¹, and Arnold Ng^4,5

¹Queensland University of Technology, Brisbane, Australia, ²Translational Research Institute, Woolloongabba, Australia, ³Endocrinology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁴Cardiology, Princess Alexandra Hospital, Woolloongabba, Australia, ⁵The University of New South Wales, Sydney, Australia

VARPRO is a novel fat water separation sequence that shows promise for myocardial lipid characterization. Two questions were addressed in this study: 1. Does VARPRO provide the same myocardial fat-fraction result compared to established magnetic resonance spectroscopy (MRS)? 2. Is the myocardial fat-fraction obtained by VARPRO reproducible? The results suggest the two methods are strongly associated but agreed poorly. The VARPRO estimation is proportionally biased, however, the bias can be easily accounted for using a linear equation. The temporal reproducibility of VARPRO is satisfactory. VARPRO could be a potential, alternative modality to MRS in myocardial lipid quantification.

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