The current classification of heart failure based on diastolic and systolic dysfunction limits the understanding of the time course of heart failure with preserved left ventricular ejection fraction (HFpEF), and new parameters are warranted to assess cardiac function. Here, we assessed global longitudinal strain (GLS), as well as hemodynamic forces (HDF) in a mouse model of diabetes (db/db) at two time points, with the aim to study the prognostic value of these new parameters for cardiac dysfunction.
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