Hypertrophic cardiomyopathy (HCM) is the most frequent inherited monogenic heart disease and could lead to heart failure or even sudden cardiac death. Effective relaxation time T2* is related to different physiological parameters. Dynamic CINE mapping of T2* covering the entire cardiac cycle facilitates distinction of healthy and pathologic myocardial tissue. Here we propose, implement, evaluate and apply an effective approach of retrospective cardiac gating that affords for the first time CINE T2*-mapping in mice at 9.4T and provides the technological basis for translational research into a deeper understanding of the mechanisms underlying hypertrophic cardiomyopathy.
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