Abstract #2054

Fast T1rho mapping in mice using an optimized Bloch simulation based radial sampling pattern

Maximilian Gram^1,2, Daniel Gensler^1,3, Patrick Winter^1,2, Michael Seethaler^2,3, Peter Nordbeck^1,3, and Peter Jakob²

¹Department of Internal Medicine I, University Hospital Würzburg, Würzburg, Germany, ²Experimental Physics 5, University of Würzburg, Würzburg, Germany, ³Comprehensive Heart Failure Center (CHFC), University Hospital Würzburg, Würzburg, Germany

Myocardial T_1ρ-mapping in small animal studies is still a challenging procedure. Commonly, T_1ρ-mapping requires long measurement times or only provides insufficient image quality due to a low signal-to-noise-ratio. Using a novel approach based on an optimized radial sampling pattern and high flip angles, we were able to overcome both restrictions. By a special sorting of golden angles based on Bloch simulations the image quality of the method could be significantly increased, and a high quantification accuracy could be realized. Thus, the new approach is a reliable method for fast T_1ρ-mapping in future studies on small animals.

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