Abstract #2025

Troponin T is a potential indicator for nerve damage in Type 2 Diabetes - results from Diffusion Tensor Imaging of the sciatic nerve

Johann Malte Enno Jende¹, Stefan Kopf², Zoltan Kender², Artur Hahn¹, Jakob Morgenstern³, Peter Paul Nawroth², Martin Bendszus¹, and Felix Tobias Kurz¹

¹Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, ²Internal Medicine I / Endocrinology, Heidelberg University Hospital, Heidelberg, Germany, ³Laboratory medicine, Heidelberg University Hospital, Heidelberg, Germany

Diabetic neuropathy (DN) is one of the most severe complications of Diabetes mellitus. This study sought to investigate potential correlations between high sensitivity Troponin T (hsTNT) assays and peripheral nerve fractional anisotropy (FA) in diffusion tensor imaging (DTI) in 51 patients with diabetes. We found negative correlations of hsTNT with the sciatic nerve's FA (r=-0.52;p<0.001) and sural, tibial, and peroneal nerve conduction velocities (0.65,p<0.001; r=-0.44,p=0.002, and r=-0.42,p=0.003, respectively). Our results indicate that hsTNT is a potential marker for microangiopathy-related nerve damage in diabetic neuropathy.

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