Dark rearing (DR) profoundly affects visual processing. Decreased flash responsiveness and increased off-response latencies were reported in DR mice visual cortex (VC). Here, we targeted such plastic changes in activation dynamics using ultrafast fMRI upon mice monocular visual stimulation. Our results, targeting the most of the pathway, showed decreased BOLD amplitudes in most visual pathway structures as well as less well-defined neuronal input order. Activation maps revealed marked increases in ipsilateral response in DR mice compared to controls. These results reveal that BOLD fMRI can depict visual pathway plasticity, and suggests a naïve and unskilled network upon DR.
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