The OCD symptoms affect to abnormal functional activity and connectivity at caudate nucleus during memory retrieval, and lead to GM volume changes

For verifying how the OCD symptom affects to abnormal functional activity and connectivity at Cd during memory processing, and whether leading to brain volume changes in direct or indirect, we performed multi study combined with fMRI and VBM study. Twenty OCD patients and 20 controls took part in VBM and fMRI studies with explicit memory task. The functional and morphological profiles of Cd could be emphasized to abnormal processing of explicit memory by OCD symptoms. It puts forward a possibility that focal functional connectivity and brain volume changes may be affected by lasting OCD symptoms, and leading to memory dysfunction.