Using seed based FC analysis, we investigated alterations in functional connectivity of amygdala subregions in OCD. Our findings (ⅰ) indicated OCD patients, relative to HC, have anomalous amygdala resting state network connections to brain regions that play a pivotal role in emotional processing; (ⅱ) identified CM/Astr-PCG hyperconnectivity and CM-cuneus hyperconnectivity, which were not detected when using the whole amygdala as a seed; (ⅲ) demonstrated FC measures of significant regions were correlated with illness duration and symptom severity. Besides, we found that functional aberrations were accompanied with anatomical changes in OCD. These findings may contribute to revealing the pathophysiology underlying OCD.
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