Abstract #1983

Subanesthetic ketamine infusion increases oxidative metabolism in human prefrontal cortex

Naomi R. Driesen^1,2, Peter Herman³, Margaret Rowland^1,2, Maolin Qiu³, George He⁴, Peter T. Morgan¹, Andrea Diaz-Stansky¹, Sarah Fineberg¹, Daniel Barron¹, Lars Helgeson⁵, Robert Chow⁵, Ralitza Gueorguieva⁶, Teo-Carlo Straun⁷, John H. Krystal^1,2, and Fahmeed Hyder^3,8

¹Psychiatry, Connecticut Mental Health Center, Yale University, New Haven, CT, United States, ²VA Connecticut Health Care System, West Haven, CT, United States, ³Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ⁴Psychology, Yale University, New Haven, CT, United States, ⁵Anesthesiology, Yale University, New Haven, CT, United States, ⁶Yale School of Public Health, Yale University, New Haven, CT, United States, ⁷Straun Health and Wellness, New Haven, CT, United States, ⁸Biomedical Engineering, Yale University, New Haven, CT, United States

We compared the effect of subanesthetic infusion of the NMDA receptor antagonist ketamine on metabolic activity to a similar volume of saline infusion in healthy volunteers. Since BOLD fMRI depends on neurovascular-neurometabolic couplings which can be confounded by pharmacological agents, we measured transverse relaxation rates (R₂, R₂*) and blood flow (CBF) to calculate oxidative metabolism (CMR_O2) with calibrated fMRI. We found CBF and CMR_O2 increased with ketamine infusion in nearly all Brodmann areas of the cortex. The CMR_O2 increase was significant in prefrontal (0.16±0.06, p=0.026) and visual cortex (0.22±0.07, p=0.01), but not in sensorimotor cortex (0.17±0.14, p=0.258).

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