Abstract #1955

In vivo detection of neuroinflammation in rats using Manganese-Enhanced MRI (MEMRI)

Satoshi Fujiwara¹, Sosuke Yoshinaga¹, Shigeto Iwamoto¹, Sayaka Shibata², Aiko Sekita², Nobuhiro Nitta², Tsuneo Saga², Ichio Aoki², and Hiroaki Terasawa¹

¹Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, ²Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan

Neuroinflammation is initiated by many types of neural disorders as a defensive response of the innate immune system in the central nervous system (CNS). Neuroinflammation is typically accompanied by the disruption of Ca²⁺ homeostasis. Manganese chloride (MnCl₂) is a useful positive MRI contrast agent that enters activated cells through Ca²⁺ channels, and is utilized in Manganese-Enhanced MRI (MEMRI) for functional neuroimaging. We sought to determine whether MEMRI could be used to assess the cellular/molecular alterations caused by acute neuroinflammation in vivo, by focusing on Mn²⁺ accumulation in the rodent brain.

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