Abstract #1948

Quantitative in vivo 19F MRI of mouse brain inflammation using a cryogenic RF surface probe and RARE

Paula Ramos Delgado¹, Christian Prinz¹, Jason M. Millward¹, Helmar Waiczies², Ludger Starke¹, Joao Periquito¹, Laura Boehmert¹, Thoralf Niendorf^1,3, Andreas Pohlmann¹, and Sonia Waiczies¹

¹Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ²MRI.tools GmbH, Berlin, Germany, ³Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

The low SNR inherent to fluorine (¹⁹F) MRI necessitates sensitivity-enhancing methods. SNR-efficient imaging techniques such as RARE and SNR-enhancing cryogenically-cooled RF coils (CRP) create new challenges. The strong spatially-varying B₁ fields of transceive surface RF coils hamper quantification and no analytical signal intensity equation for B₁⁺ correction exists for RARE. We developed a B₁ correction method that makes use of experimental data to model the signal intensity from RARE and we established a workflow to correct and quantify ¹⁹F MR signals originating from inflammatory regions of the mouse brain that were acquired using a ¹⁹F-CRP.

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