Abstract #1919

Age-related hyperactivity of brain oxygen metabolism in a novel Tau-APP mouse model of Alzheimer’s disease

Zhiliang Wei^1,2, Jiadi Xu^1,2, Kerstin E. Braunstein³, Lin Chen^1,2, Tong Li³, Philip C. Wong³, and Hanzhang Lu^1,2,4

¹Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Research Institute, Baltimore, MD, United States, ³Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Alzheimer’s disease (AD) has been the leading cause of cognitive impairment and decline in elder individuals. Cross-sectional human studies have reported declined cerebral oxygen metabolism in AD patients tentatively attributed to reduced neuron cells. However, longitudinal change in oxygen metabolism remains unclear. We, therefore, performed a multi-modality (MRI, behavior test, and histology) study on a novel AD mouse model, dubbed as Tau4RΔK-AP, which largely mimics the pathological processes of tau-tangles and amyloid plaques as in human AD. Enhanced oxygen metabolism has been found in Tau4RΔK-AP mice, possibly indicating a compensatory response or an inefficiency of the brain energy consumption.

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