The purpose of this study is to determine whether magnetic resonance spectroscopic imaging (MRSI) can identify metabolite biomarkers of HIV infection in the brain. Concentrations of N-acetyl aspartate (NAA), choline (CHO), creatine (CR), myo-inositol (MI), and glutamate and glutamine (GLX) were measured at the whole-brain level and compared between HIV+ and healthy control subjects. Significant reductions in NAA and increases in MI are observed throughout the brain, while the concentrations of other metabolites show no significant change.
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