Abstract #1819

Microscopic fractional anisotropy measurements from double diffusion encoding for human brain tumor diagnosis

Masaaki Hori^1,2, Masanori Ozaki³, Hiroshi Kusahara⁴, Masahiro Abe⁴, Shuji Sato⁵, Seiko Shimizu⁶, Kouhei Kamiya^1,7, Toshiaki Akashi², Koji Kamagata², and Shigeki Aoki²

¹Toho University Omori Medical Center, Tokyo, Japan, ²Radiology, Juntendo University School of Medicine, Tokyo, Japan, ³Research and Development Center, Canon Medical Systems Corporation, Kanagawa, Japan, ⁴Advanced MRI development PJ Team, Canon Medical Systems Corporation, Kanagawa, Japan, ⁵Juntendo University Hospital, Tokyo, Japan, ⁶Canon Medical Systems Corporation, Tokyo, Japan, ⁷Radiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan

We investigated the values and image contrast of μFA using double diffusion encoding in patients with brain tumors in vivo, as a preliminary study. In general, μFA showed higher values than FA did in the brain tumors. There is no correlation among μFA and FA and ADC, in the meningiomas and solid part of glioblastoma and malignant lymphoma. However, more investigation will be needed to establish the usefulness of μFA in clinical use.

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