Abstract #1781

Cerebral oxygen extraction fraction mapping: comparison of dual-gas challenge calibrated BOLD and challenge-free gradient echo QSM+qBOLD

Junghun Cho¹, Yuhan Ma², Pascal Spincemaille³, Bruce Pike^2,4, and Yi Wang^1,3

¹Biomedical Engineering, Cornell University, New York, NY, United States, ²McConnell Brain Imaging Centre, McGill University, Montreal, QC, Canada, ³Radiology, Weill Cornell Medical College, New York, NY, United States, ⁴Radiology, University of Calgary, Calgary, AB, Canada

In this study, we compare cerebral oxygen extraction fraction (OEF) and metabolic rate of oxygen consumption (CMRO2) maps obtained using dual-gas challenge calibrated-BOLD (DGC) and challenge-free gradient echo quantitative susceptibility mapping plus quantitative blood oxygen level-dependent modeling (QSM+qBOLD or QQ) to explore the important clinical advantage of challenging-free data acquisition. In n=11 healthy subjects, cortical gray matter average OEF was not significantly different (36.4±1.9% and 38.0±9.1%, P=0.63) as was CMRO2 (151.4±17.6 and 168.2±54.1 μmolO2/min/100g, P=0.26), for QQ and DGC, respectively. QQ can measure OEF and CMRO2 at both baseline and hypercapnia independently, showing a 14% CMRO2 decrease in hypercapnia (P=0.039).

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