Abstract #1759

Postmortem Whole-Brain MP2RAGE Optimization at 3T: A New Imaging Window into Multiple Sclerosis Cortical Pathology

Matthias Weigel^1,2,3, Riccardo Galbusera^1,2, Reza Rahmanzadeh^1,2, Muhamed Barakovic^1,2, Po-Jui Lu^1,2, Ludwig Kappos², Wolfgang Brück⁴, Tobias Kober^5,6,7, Peter Dechent⁸, and Cristina Granziera^1,2

¹Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ²Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ³Radiological Physics, Department of Radiology, University Hospital Basel, Basel, Switzerland, ⁴Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare, Lausanne, Switzerland, ⁶Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ⁷LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁸Department of Cognitive Neurology, MR-Research in Neurology and Psychiatry, University Medical Center Göttingen, Göttingen, Germany

The MP2RAGE sequence provides fast volumetric T1 weighted MR imaging and offers the possibility to reconstruct quantitative T1 maps. Therefore, it is frequently applied for studying Multiple Sclerosis pathologies in recent years. The present work investigates and explains necessary protocol changes for applying MP2RAGE in fixated human brain acquisitions. Using the established protocol, it is shown that strong soft tissue contrast is reinstated and quantitative T1 values can be derived for normal appearing gray matter and lesions. Based on the feasibility of using long scan times, the isotropic resolution of the MP2RAGE could be even increased to 0.75mm.

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