Abstract #1737

Along-tract quantitative analysis of arcuate fasciculus for awake glioma surgery

Lia Talozzi¹, Matteo Martinoni², Micaela Mitolo ³, Filippo Badaloni², Sofia Asioli^1,4, Claudia Testa⁵, Raffaele Lodi^1,6, and Caterina Tonon^1,3

¹Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, ²IRCCS Istituto delle Scienze Neurologiche di Bologna, Neurosurgery Unit, Bologna, Italy, ³IRCCS Istituto delle Scienze Neurologiche di Bologna, Neuroradiology Functional Diagnostic Unit, Bologna, Italy, ⁴Section of Anatomic Pathology 'M. Malpighi', Bellaria Hospital, Bologna, Italy, ⁵Physics and Astronomy, University of Bologna, Bologna, Italy, ⁶, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy

Probabilistic arcuate fasciculus (AF) tractography was computed in healthy controls (HC) and for a patient with a diffuse glioma, IDH 1 wild type left frontal lobe. Bilateral curvature mapping and along-tract DTI measures were evaluated, modelling surface geometry. In HC, hemispheric asymmetries in tract curvature showed a more lateral and inferior trajectory on the left, not measured for the patient’s left AF, medially dislocated. In HC, a left-lateralized asymmetries (higher FA and volume) was measured, and it was preserved for the patient. During pre-surgical evaluation, the proposed developed tractography analyses allowed a quantitative investigation of AF dislocation and microstructural integrity.

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