We used 3D-TOF-MRA and territorial-ASL (t-ASL) maps to investigate the relationship between anatomical morphology of circle of Willis (CoW) and the primary collateral blood flow in physiological conditions. We found that the primary collateral blood flow had a direct relationship with anatomical structure of CoW. A1 segment has a role in controlling the blood flow in anterior circulation, while in posterior circulation, P1 segment and PcomA cooperate to dominate the blood flow.
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