The Windkessel effect is hypothesized to be the mechanism of altered cerebral hemodynamics in intracranial aneurysms, via damping of pulsatile flow. 4D Flow MRI with specialized, network-based post-processing workflow provides damping factor (DF), by measuring pulsatility index (PI) ratio between proximal and distal vessels. PI values were higher in subjects with large aneurysms, even for contralateral vessels, suggesting patients with larger aneurysms may have other contributions to hemodynamics that also impact their vasculature outside the lesion. A multivariate linear correlation model shows that smaller aneurysms may have lower DF than contralateral, while larger aneurysms have higher DF ipsilateral than contralateral.
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