Abstract #1585

Detection of brain microstructural alterations in epilepsy using DTI and mean apparent propagator (MAP)-MRI

Weike Zeng¹, Mengzhu Wang², Xu Yan³, and Guang Yang⁴

¹Deptpartment of Radiology, SUN YAT-SEN Memorial Hospital, SUN YAT-SEN University, Guangzhou, China, ²MR Scientific Marketing, Siemens Healthcare, Guangzhou, China, ³MR Scientific Marketing, Siemens Healthineers, Shanghai, China, ⁴Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China

We investigated the clinical feasibility of characterizing brain tissue microstructure in epilepsy with mean apparent propagator (MAP)-MRI, and compared with diffusion tensor imaging (DTI) using whole-brain voxel-based analyses. Results demonstrated that the MAP-MRI microstructural parameters could potentially provide more sensitive clinical biomarkers than conventional DTI techniques due to increased pathophysiological speciﬁcity in microstructural changes detection.

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