Abstract #1582

Diffusion Tensor Metrics Abnormalities in Developing brain: A Comparative Study Between Epilepsy and Simple Febrile Seizure aged 6-60 months

Abdelkareem Salimeen Mustafa¹, Xianjun Li¹, Miaomiao Wang¹, Congcong Liu¹, Martha Singh¹, Mengxuan Li ¹, Xiaocheng Wei², and Jian Yang^1,3

¹First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China, Xi’an, China, ²MR Research China, GE Healthcare, China, Beijing, China,, Beijing, China, ³The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, People’s Republic of China,, Xi’an, China

Epilepsy is a common neurological disorder spread worldwide. Simple febrile seizures (simple FS) is convulsive disorder associated with fever. However, little known about diffusion changes during the developing brain. The study aimed was to assess the diffusion changes in epilepsy and simple FS at aged of 6 to 60 months, using diffusion tensor imaging (DTI). Through inter-group comparisons, fraction anisotropy (FA) decreased, and radial diffusivity (RD) increased in epileptic children compared to simple FS and control. These results suggested DTI is sensitive method in diagnosis delayed myelination in epilepsy, while simple FS have good prognosis due to different pathophysiological mechanism.

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