This study performed a voxel-based morphometry to investigate global gray matter changes in patients with acute CO intoxication. The results show significantly decreased gray matter volumes mostly in the pain-matrix regions, and significantly increased gray matter volumes in the periaqueductal gray (pain-modulating center). In the pain-matrix regions, the GM volumes were significantly negatively correlated with duration of coma, suggesting that longer duration of coma may lead to more headache symptoms in patients with acute CO intoxication.
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