Abstract #1563

Comparison of brain atrophy in patients with type 2 diabetes from the Diabetes and Dementia (D2) study and stroke patients from the CANVAS study

Mohamed Salah Khlif¹, Carolina Restrepo¹, Emilio Werden¹, Laura Bird¹, Sheila K. Patel^1,2, Rebecca Singleton¹, Jeffrey D. Zajac^2,3, Richard MacIsaac⁴, Elif I. Ekinci^2,3, Louise M. Burrell^2,5, and Amy Brodtmann^1,2,6

¹The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, ²Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Australia, ³Austin Health Endocrine Centre, Heidelberg, Australia, ⁴Department of Endocrinology & Diabetes, St Vincent's Hospital, Melbourne, Australia, ⁵Department of Cardiology, Austin Health, Heidelberg, Australia, ⁶Department of Neurology, Austin Health, Heidelberg, Australia

Type 2 diabetes and stroke are associated with reduced brain volumes and independently present a high risk for cognitive impairment or dementia. The interaction between diabetes and stroke and its effects on brain atrophy are unknown. We used linear mixed-effect modelling to estimate rates of atrophy over two years based on FreeSurfer segmentation of MR images of healthy participants and patients with type 2 diabetes and/or stroke. Cerebral atrophy, defined by volume reductions in specific regions of interest, was accelerated the most in the group with only type 2 diabetes. Thalamus was affected more by stroke.

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