Abstract #1551

Increases in Arteriolar Cerebral Blood Volume in Huntington’s Disease Measured with Inflow-based Vascular-space-occupancy (iVASO) MRI at 7T

Chunming Gu^1,2,3, Martin Kronenbuerger^4,5, Di Cao^1,2,3, Adrian G. Paez^1,2, Xinyuan Miao^1,2, Xirui Hou^1,3, Jee Bang^5,6, Kia E. Ultz⁵, Wenzhen Duan^6,7, Russell L. Margolis^5,6, Peter C. M. van Zijl^1,2, Christopher A. Ross^5,6,7,8, and Jun Hua^1,2

¹The Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States, ⁴Department of Neurology, University of Greifswald, Greifswald, Germany, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁷The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁸Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Significantly elevated arteriolar cerebral blood volume (CBVa) in premanifest Huntington’s Disease (HD) patients has been reported previously. In this study, inflow-based vascular-space-occupancy (iVASO) MRI at 7 Tesla was used to measure CBVa in HD patients longitudinally. We found significant longitudinal increases in CBVa in premanifest HD patients in several brain regions primarily related to motor, visual and cognitive functions, which suggests CBVa as a potential candidate biomarker for HD especially in the premanifest stage.

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