Abstract #1537

Investigation of the Global Volumetry and Relaxometry of the Brain in Parkinson's Disease using Synthetic MRI

Na Lu^1,2, Chunmei Li¹, Shuhua Li³, Pu-Yeh Wu⁴, Wen Su³, Haibo Chen³, and Min Chen^1,2

¹Department of Radiology, Beijing Hospital, National Center of Gerontology, Beijing, China, ²Graduate School of Peking Union Medical College, Beijing, China, ³Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing, China, ⁴GE Healthcare, MR Research China, Beijing, China

This study revealed both the brain volumetric and relaxometric characteristics from synthetic MRI technique in Parkinson's disease (PD). Significantly differences were found in fraction of gray matter (GM), white matter (WM) and myelin. We also observed significantly differences in WM T1 value, GM and CSF proton density value. Hence Synthetic MRI might be a quantitative tool for clinical diagnosis of PD.

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