Abstract #1511

Susceptibility Map-Weighted Imaging and Neuromelanin-Sensitive MRI in Parkinson’s Disease

Septian Hartono^1,2, Isabel Hui Min Chew³, Weiling Lee³, Amanda May Yeng Choo¹, Celeste Yan Teng Chen¹, Leon Qi Rong Ooi⁴, Lirong Yin³, Kuan Jin Lee⁵, Jongho Lee⁶, Ching-Yu Cheng⁷, Eng King Tan^1,2, and Ling Ling Chan^2,3

¹National Neuroscience Institute, Singapore, Singapore, ²Duke-NUS Medical School, Singapore, Singapore, ³Singapore General Hospital, Singapore, Singapore, ⁴National University of Singapore, Singapore, Singapore, ⁵Singapore BioImaging Consortium, Singapore, Singapore, ⁶Seoul National University, Seoul, Republic of Korea, ⁷Singapore Eye Research Institute, Singapore, Singapore

Nigrosome-1 imaging and neuromelanin contrast have been identified as good radiological biomarkers of dopaminergic nigral degeneration in Parkinson's disease (PD) pathology. We evaluated the sensitivity of quantitative Susceptibility-Mapping Weighted Imaging (SMWI) derived from Quantitative Susceptibility Mapping (QSM) and neuromelanin sensitive (NMS) imaging in differentiating a case control cohort of PD patients. Region-of-interest analysis of the substantia nigra on both QSM/SMWI and NMS offered excellent differentiation of PD and healthy controls. However, QSM/SMWI offered more robust disease classification compared to NMS and might be preferred for use in the clinical setting.

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