Koji Fujimoto1, Martijn A. Cloos2, Atsushi Shima3, Thuy Dinh Ha Duy1, Nobukatsu Sawamoto4, Ryosuke Takahashi3, Tadashi Isa1,5, and Tomohisa Okada1
1Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan, 2Center for Advanced Imaging Innovation and Research (CAI2R) and Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, 4Department of Human Health Sciences, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan, 5Department of Neuroscience, Kyoto University Graduate School of Medicine, Kyoto University, Kyoto, Japan
To investigate changes in T1 and
T2 of deep gray matter in Parkinson’s disease (PD) patients at 7T, healthy
volunteers (N=104, age range 20-77) and PD patients (N=42, age range 50-72)
were scanned using a 1ch-Tx/32ch-Rx coil and a Plug-and-Play MR Fingeprinting
(prototype) sequence. ROIs were drawn in six regions (left and right putamen,
globus pallidus, caudate head, thalamus, frontal white matter (WM)) and a linear
and quadratic curve fitting was performed. T2 value of the putamen was larger
in PD than the age-matched subgroup of HC, but was not significant.
