Abstract #1507

Insula structural changes and behavioral disinhibition in Parkinson’s Disease

Megan Aumann^1,2, Kathleen Larson³, Elise Bradley⁴, David Zald^2,5, Ipek Oguz³, and Daniel O Claassen⁶

¹Neurology, Vanderbilt University, Nashville, TN, United States, ²Psychology, Vanderbilt University, Nashville, TN, United States, ³Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ⁴Neuropsychiatry, Vanderbilt University Medical Center, Nashville, TN, United States, ⁵Psychiatry, Vanderbilt University Medical Center, Nashville, TN, United States, ⁶Neurology, Vanderbilt University Medical Center, Nashville, TN, United States

Parkinson’s Disease (PD) patients who take dopaminergic therapy are at risk for developing impulsive-compulsive behaviors, and these behaviors localize to the mesocorticolimbic regions. Using a caregiver-reported values from the Frontal Systems Behavioral Scale (FrSBe), we assessed disinhibition, apathy, and dysexecutive symptoms in 72 PD patients. All participants completed brain MRI, and we measured cortical thickness in frontal regions, assessing the relationship between cortical thickness and FrSBE scores. We find that thickness in the insula is directly related to disinhibited behaviors. These results provide new insights into how cortical changes and behavioral symptoms are linked in PD.

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