Abstract #1490

MRI subfield hippocampal volumetric analysis combined with amyloid PET result: Comparison between mild cognitive impairment, major depressive disorder and healthy elderly subjects.

Doonyaporn Wongsawaeng¹, Chanon Ngamsombat¹, Tanyaluck Thientunyakit¹, Weerasak Muangpaisan², Suwit Charoensuk³, Panida Charnchaowanish¹, and Orasa Chawalparit¹

¹Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ²Department of Geriatric Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand, ³Department of Psychiatry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, Bangkok, Thailand

Hippocampus is a part of limbic system involving both neurodegenerative disease and emotional regulation circuit. This study aimed to use MRI automated subfield hippocampal volumetric analysis to differentiate mild cognitive impairment (MCI) from major depressive disorder (MDD) and age-matched healthy elderly (HE) subjects. We found a trend of relative smaller size in several subfield hippocampal regions in MCI than MDD patients. Even though, there were no statistical significance. These may raise possibility of MRI volumetry to be the tool for discriminating early neurodegenerative disease from major depressive disorder.

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