Abstract #1456

Longitudinal trajectory of fibre-specific degeneration in Alzheimer’s disease and mild cognitive impairment

Remika Mito^1,2, Robert Smith¹, Thijs Dhollander¹, Christopher Rowe^3,4, Victor Villemagne^3,4, Amy Brodtmann^1,3, and Alan Connelly^1,2

¹Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, ²Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, Australia, ³Department of Medicine, Austin Health, University of Melbourne, Melbourne, Australia, ⁴Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Heidelberg, Australia

Alzheimer’s disease (AD) is characterised by degeneration of specific white matter tracts, however the longitudinal trajectory of tract-specific decline has not yet been well described. In this work, we utilise a longitudinal fixel-based analysis framework to investigate specific fibre tracts that exhibit accelerated decline in AD and mild cognitive impairment (MCI). Whole-brain analysis revealed that select fixels exhibit accelerated rates of decline in AD compared to healthy elderly controls, while MCI patients did not exhibit accelerated decline in any fibre structures. Tract-of-interest analysis revealed group differences in tract trajectories over time.

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